Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine

The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for Headband drug dependence and addiction.Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-induced gut dysbiosis exacerbates tolerance

read more

Numerical Investigation and Statistical Analysis of the Flow Patterns Behind Square Cylinders Arranged in a Staggered Configuration Utilizing the Lattice Boltzmann Method

Flow past bluff bodies like square cylinders is important in engineering applications, but flow patterns behind staggered Butcher cylinder arrangements remain poorly understood.Existing studies have focused on tandem or side-by-side configurations, while offset orientations have received less attention.The aim of this paper is to numerically invest

read more